Here’s one of my favourite tunes by Queensryche. “I Don’t Believe in Love” is a great example of a perfect guitar duo that constantly compliments to each other during the track.
The cool thing about this video is that I managed to play both parts in one take without having to switch presets because I used a great feature called “Automation” (available in every single DAW I suppose).
This way you can tell your computer to change parameters at exact times just like you would control your presets by stomping on individual pedals or multi-effects processors. This way you just focus on your playing and let the computer switch your lead, rhythm, cleans…etc